Masteron is well-known for being one of the only anabolic steroids with strong anti-estrogenic properties. Not only does this steroid carry no estrogenic activity, but it can actually act as an anti-estrogen in the body. This is why it has been effective in the treatment of breast cancer. In fact, the combination of Masteron and Nolvadex (Tamoxifen Citrate) has been shown to be far more effective than chemotherapy in the treatment of inoperable breast cancer in postmenopausal women. This also makes it a popular steroid among bodybuilders as it could actually prohibit the need for an anti-estrogen when used in the right cycle. This will also prove advantageous during the cutting phase due to the hardening effects it can provide.